top of page


The Yıldız lab studies biofilms, microbial communities composed of microorganisms encased in an extracellular matrix. To understand the processes and consequences of biofilm formation, we have developed an interdisciplinary research program that addresses critical questions regarding the molecular mechanisms of biofilm formation.



We use Vibrio cholerae, the causative agent of cholera, as a model organism to study biofilms. V. cholerae is a facultative human pathogen; it proliferates within the human intestine and grows and survives for prolonged periods in aquatic habitats. V. cholerae forms biofilms both in the environment and in human hosts. V. cholerae’s ability to form biofilms is crucial for its survival in aquatic habitats between epidemics and is advantageous for host-to-host transmission during outbreaks.

Model vibrio infection cycle.png

Our studies are grounded in genetic and biochemical analyses combined with functional genomics and extensive phenotypic characterization. We collaborate with leading experts to supplement our studies with quantitative biophysical approaches, structural biology, super-resolution imaging, and modeling.   Our approach is characterized by the incorporation of state-of-the-art techniques that allow us to understand the molecular mechanisms of biofilm biology. Our work has resulted in a fundamental understanding of molecular mechanisms of biofilm formation and regulatory circuitries, as well as the role of biofilms in pathogenesis.

bottom of page